How RNA and proteins work together to control gene expression
Assembly Mechanisms of RNA-Protein Complexes for Genetic Control
This study is looking at how RNA and proteins work together to help our genes do their job, using special tools to see how they interact and change shape, which could help us understand diseases that happen when these processes go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11011974 on NIH RePORTER |
What this research studies
This research investigates the assembly mechanisms of RNA-protein complexes that play a crucial role in gene expression. By using advanced techniques like single molecule fluorescence microscopy, the research aims to visualize how RNA and proteins interact and change shape during the process of transcription. The study focuses on understanding the dynamics of these interactions in model systems such as bacteria and yeast, which can provide insights into how defects in these processes may lead to various diseases. Ultimately, the goal is to uncover the physical principles governing RNA-protein assembly to inform potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders, metabolic diseases, or those at high risk for cancer due to RNA-protein interaction defects.
Not a fit: Patients with conditions unrelated to RNA-protein interactions or those not affected by genetic or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating developmental disorders, metabolic dysfunctions, and high-risk cancers.
How similar studies have performed: Previous research has shown promising results in understanding RNA-protein interactions, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Woodson, Sarah a. — Johns Hopkins University
- Study coordinator: Woodson, Sarah a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.