How RNA affects gene regulation and inheritance in tiny worms.
Official title: RNA-mediated Chromatin Regulation and Transgenerational Epigenetic Inheritance in C. elegans
Funded at Rutgers, the State Univ of N.j. · NIH-11141587 · Data updated 2026-11-12
This study is looking at how tiny RNA molecules can control genes and pass traits down through generations in roundworms, helping us understand how certain changes in their DNA can keep them healthy and live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $392,500 |
| NIH project number | 5R35GM152219-02 |
| Project ID | NIH-11141587 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals interested in the genetic and epigenetic mechanisms of aging and inheritance, particularly those with a background in genetics or molecular biology.
✕Less likely to help
Patients with no interest in genetic research or those not engaged in scientific study may not find direct benefits from this research.
What this research studies
This research investigates how RNA molecules can regulate gene expression and influence inheritance patterns in the roundworm C. elegans. By using a method called nuclear RNA interference (RNAi), the study aims to understand how specific modifications to chromatin, the material that makes up chromosomes, can affect gene silencing across generations. The researchers will employ genetic, genomic, and biochemical techniques to explore a novel histone modification and its role in maintaining genome stability and promoting longevity in these organisms.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and inheritance, potentially leading to breakthroughs in treating age-related diseases and genetic disorders.
How similar studies have gone: Previous research has shown success in using RNA interference techniques in various organisms, indicating that this approach has a solid foundation in scientific literature.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Gu, Guoping — Rutgers, the State Univ of N.j.
- Study coordinator: Gu, Guoping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.