How RIG-I sensors control lung inflammation and repair
RIG-I-like receptor regulation of pulmonary inflammation and homeostasis
Looks at whether changing RIG-I signaling in the lungs can reduce harmful inflammation and help lungs heal after infection or injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11141203 on NIH RePORTER |
What this research studies
This project studies RIG-I-like receptors, proteins that detect nucleic acids inside cells, to understand how they control lung inflammation and tissue repair. Researchers will use lab-grown lung cells and preclinical lung models to test how a synthetic RIG-I agonist and type III interferon (IFN-λ) change immune cell programming and healing responses. The team will map signaling pathways that shift responses away from damaging inflammation toward tissue repair. Results are intended to point to molecular targets that could be used to develop new treatments for infectious and non-infectious lung inflammation.
Who could benefit from this research
Good fit: People with inflammatory lung conditions such as severe viral pneumonia, acute lung injury, or other inflammatory lung diseases would be most relevant for future therapies.
Not a fit: People without lung inflammation or with unrelated non-pulmonary conditions are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: Could identify new drug targets to reduce lung inflammation and speed recovery after lung infections or injury.
How similar studies have performed: Early laboratory and animal studies suggest RIG-I agonists and IFN-λ can alter immune responses and help lung repair, but testing in patients remains novel.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Hemann, Emily Ann — Ohio State University
- Study coordinator: Hemann, Emily Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.