How ribosomes maintain reading frames during stalling
Reading frame maintenance by the ribosome during stalling
This study looks at how tiny machines in our cells, called ribosomes, keep reading instructions from our genes correctly, even when they hit bumps in the road, which is important for making the proteins our bodies need to function well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10800689 on NIH RePORTER |
What this research studies
This research investigates how ribosomes, the cellular machinery that translates genetic information into proteins, maintain the correct reading frame when they encounter stalling. The study focuses on the mechanisms that prevent errors during protein synthesis, particularly how ribosomes manage to read messenger RNA (mRNA) accurately despite potential disruptions. By examining the interactions between mRNA, transfer RNA (tRNA), and ribosomal components, the research aims to uncover the cellular responses to ribosome stalling and the implications for protein production. This work could provide insights into the fundamental processes of gene expression and protein synthesis.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with genetic disorders or diseases linked to protein synthesis errors.
Not a fit: Patients with conditions unrelated to protein synthesis or ribosomal function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of protein synthesis errors, potentially informing treatments for diseases caused by such errors.
How similar studies have performed: Previous research has shown success in understanding ribosome function and its implications for protein synthesis, making this approach a continuation of established scientific inquiry.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Zaher, Hani — Washington University
- Study coordinator: Zaher, Hani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.