How ribosomal proteins influence blood cell production
Regulation of hematopoiesis by ribosomal protein paralogs
This project looks at how certain ribosomal proteins affect the making of blood cells in adults, which could be relevant to blood disorders like leukemia.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11251561 on NIH RePORTER |
What this research studies
The team is studying specific ribosomal proteins that may act outside the ribosome to control how different blood cells form. They use genetically modified mice that disrupt the interaction between the ribosomal protein Rpl22 and its partner hnRNP-A1, together with laboratory cell and protein experiments, to separate ribosome-based from extraribosomal effects. By clarifying these mechanisms, the researchers aim to explain why some blood cell types are selectively affected and how that could contribute to diseases such as acute leukemia. This work is primarily laboratory and animal-based and is conducted at Fox Chase Cancer Center.
Who could benefit from this research
Good fit: Adults with blood disorders such as acute leukemia would be the most likely to benefit from advances emerging from this research.
Not a fit: People without blood disorders and children (under 21) are unlikely to receive direct benefit from this project in the near term.
Why it matters
Potential benefit: If successful, this work could point to new molecular targets that lead to better treatments for blood disorders and certain leukemias.
How similar studies have performed: The team has prior evidence that Rpl22 has extraribosomal roles in blood development, but applying this approach more broadly to hematopoiesis and disease is relatively new.
Where this research is happening
Philadelphia, United States
- Research Inst of Fox Chase Can Ctr — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wiest, David L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Wiest, David L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.