How ribosomal proteins affect blood cell development and function
Official title: Regulation of hematopoiesis by ribosomal protein paralogs
Funded at Research Inst of Fox Chase Can Ctr · NIH-10977139 · Data updated 2026-11-12
This study is looking at a special protein called Rpl22 to see how it helps make and control blood cells, which could help us understand blood-related diseases like leukemia, and it's being done using mice that have been modified to not have this protein's usual partner.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $690,669 |
| NIH project number | 4R37AI110985-11 |
| Project ID | NIH-10977139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who are at risk for or diagnosed with blood cell-related disorders, particularly acute leukemia.
✕Less likely to help
Patients with blood disorders unrelated to the mechanisms being studied, or those over 21 years old, may not benefit from this research.
What this research studies
This research investigates the role of ribosomal proteins in the formation and regulation of blood cells, particularly focusing on a specific ribosomal protein called Rpl22. The study aims to understand how Rpl22 functions outside of the ribosome to influence hematopoiesis, the process of blood cell formation. By using genetically modified mice that lack the interaction between Rpl22 and its cofactor, the researchers will explore the implications of this interaction on blood cell development and related diseases. This could provide insights into how disruptions in these processes may lead to conditions like acute leukemia.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating blood disorders, including acute leukemia.
How similar studies have gone: Previous research has shown promising results in understanding the extraribosomal functions of ribosomal proteins, indicating that this approach could yield valuable insights.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Wiest, David L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Wiest, David L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.