How riboflavin depletion affects aging and lifespan
Physiology of Lifespan Extension and Metabolic Hormesis with Riboflavin Depletion
This study is looking at how reducing riboflavin, a vitamin, affects aging and lifespan in tiny worms and mice, with the hope of finding new ways to help people live healthier as they get older.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11018552 on NIH RePORTER |
What this research studies
This research investigates the effects of riboflavin depletion on aging and lifespan using the model organism C. elegans, along with murine cell lines and mouse models. The study aims to uncover the molecular mechanisms that contribute to lifespan extension associated with riboflavin depletion. By understanding how riboflavin is utilized and transported in cells, the research seeks to identify potential therapeutic targets for aging-related conditions. Patients may benefit from insights gained into metabolic processes that influence aging.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include older adults experiencing age-related metabolic issues.
Not a fit: Patients with acute riboflavin deficiency or those not experiencing aging-related conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for extending healthy lifespan and improving metabolic health in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding the biology of aging through similar metabolic approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Yerevanian, Armen I — Massachusetts General Hospital
- Study coordinator: Yerevanian, Armen I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.