How retinoic acid affects the process of embryo implantation
Retinoic acid signaling in decidualization
This study is looking at how a specific signaling process in the uterus helps prepare it for a pregnancy, which is important for women trying to conceive, especially those facing infertility or issues like endometriosis, and it hopes to find ways to improve IVF success and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11093386 on NIH RePORTER |
What this research studies
This research investigates the role of retinoic acid signaling in the process of decidualization, which is crucial for successful embryo implantation. By analyzing gene expression in human endometrial stromal cells, the study aims to understand how defects in this process can lead to infertility and adverse pregnancy outcomes. The researchers utilize advanced techniques, including high throughput screening, to explore the genetic factors involved in decidualization. This could lead to improved strategies for enhancing IVF success rates and developing new treatments for conditions like endometriosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing infertility, particularly those with a history of implantation failure during natural or assisted reproductive techniques.
Not a fit: Patients who are not experiencing infertility or have no history of implantation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the chances of successful pregnancies for individuals facing infertility issues.
How similar studies have performed: Previous research has shown promising results in understanding the genetic mechanisms of implantation, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ma, Liang — Washington University
- Study coordinator: Ma, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.