How retinoic acid affects immune cells in tumors
Regulation of antigen presenting cells in the tumor microenvironment by retinoic acid
This study is looking at how a Vitamin A compound called retinoic acid affects immune cells in tumors, with the hope of finding new ways to help the immune system better fight cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11041056 on NIH RePORTER |
What this research studies
This research investigates how retinoic acid, a compound derived from Vitamin A, influences the behavior of immune cells within the tumor microenvironment. The study aims to understand why certain immune cells, specifically antigen-presenting cells, fail to activate anti-tumor responses in solid tumors. By using advanced mouse models, researchers will explore the mechanisms by which retinoic acid alters the differentiation of immune cells, potentially leading to new strategies for enhancing cancer immunotherapy. The ultimate goal is to improve the effectiveness of treatments that harness the immune system to fight cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who may benefit from enhanced immune responses to their cancer.
Not a fit: Patients with non-solid tumors or those who do not have a functioning immune system may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies that enhance the body's ability to fight cancer.
How similar studies have performed: Previous research has shown promising results in enhancing anti-tumor immunity through manipulation of immune cell behavior, indicating potential success for this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Haldar, Malay — University of Pennsylvania
- Study coordinator: Haldar, Malay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.