How REST affects opioid receptors in chronic pain models
REST-mediated regulation of opioid receptors in chronic pain mouse models
This study is looking at how a protein called REST affects the way opioid painkillers work in mice with long-lasting nerve pain, hoping to find better ways to manage pain without causing problems like tolerance or addiction, which could help people dealing with chronic pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11128933 on NIH RePORTER |
What this research studies
This research investigates the role of REST, an epigenetic regulator, in the regulation of opioid receptors in mouse models of chronic neuropathic pain. By examining how REST influences the expression of opioid receptors, the study aims to uncover new strategies to enhance the effectiveness of opioid analgesics while minimizing their adverse effects, such as tolerance and addiction. The research utilizes advanced techniques to manipulate REST levels and observe the resulting changes in pain response and opioid efficacy. This could lead to improved pain management options for patients suffering from chronic pain conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic neuropathic pain, particularly those who have not responded well to standard opioid treatments.
Not a fit: Patients with acute pain conditions or those who do not have chronic neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain relief strategies that reduce the need for high doses of opioids and lower the risk of addiction.
How similar studies have performed: Other research has shown promising results in manipulating opioid receptor pathways, suggesting that this approach may yield significant advancements in pain management.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Majumder, Sadhan — University of Tx Md Anderson Can Ctr
- Study coordinator: Majumder, Sadhan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.