How respiratory syncytial virus and pollution affect airway barriers
Mechanisms of Airway Epithelial Barrier Dysfunction by Respiratory Syncytial Virus and Environmental Stimuli
This study is looking at how the respiratory syncytial virus (RSV) makes it harder for your lungs to stay protected and how tiny particles in the air can make this problem worse, with the goal of finding new ways to help keep your lungs healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10657436 on NIH RePORTER |
What this research studies
This research investigates how respiratory syncytial virus (RSV) disrupts the airway epithelial barrier, which is crucial for protecting the lungs. It focuses on the mechanisms by which RSV infection leads to a 'leaky airway' by affecting the structures that hold cells together. The study also examines how exposure to environmental pollutants, particularly nanoparticles, can worsen the effects of RSV on the airway barrier. By understanding these interactions, the research aims to identify potential therapeutic targets to improve lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and high-risk adults who are susceptible to respiratory infections, particularly those with a history of RSV infection or exposure to air pollution.
Not a fit: Patients with stable respiratory conditions who are not at risk for respiratory infections may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that strengthen airway barriers and reduce the severity of respiratory infections.
How similar studies have performed: Previous research has shown that understanding the mechanisms of viral infections and environmental factors can lead to significant advancements in treating respiratory diseases, indicating a promising avenue for this study.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Rezaee, Fariba — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Rezaee, Fariba
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.