How repeat influenza vaccinations affect immune responses
The "Dynamics of the immune responses to repeat influenza vaccination exposures" (DRIVE) Study
This study is looking at how getting the flu vaccine multiple times affects the immune system in adults, and it's for people in Hong Kong who want to help researchers understand how to make flu shots work better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10903914 on NIH RePORTER |
What this research studies
This research investigates how repeated influenza vaccinations influence the immune response in adults. By conducting a randomized clinical trial with approximately 820 participants in Hong Kong, the study aims to understand the immunological factors that contribute to the effectiveness of the vaccine. Participants will be divided into groups receiving either the vaccine or a placebo over multiple years, allowing researchers to analyze differences in antibody responses. The findings could help improve vaccination strategies and inform the development of more effective vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have low vaccination coverage and are not currently recommended for influenza vaccination.
Not a fit: Patients who are already receiving regular influenza vaccinations or those with contraindications to vaccination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved influenza vaccination strategies that enhance immune responses and vaccine effectiveness.
How similar studies have performed: Previous research has shown varying effects of repeat vaccinations on immune responses, but this specific approach is novel and aims to fill gaps in understanding.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Cobey, Sarah — University of Chicago
- Study coordinator: Cobey, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.