How renal nerves affect chronic kidney disease
Effect of Renal Nerves on Chronic Kidney Disease
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11051848
This study is looking at how nerves in the kidneys might affect chronic kidney disease and high blood pressure, and it hopes to find new treatment options for people with CKD who haven't had success with current therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11051848 on ClinicalTrials.gov |
What this research studies
This research investigates the role of renal nerves in chronic kidney disease (CKD) and how their activity may contribute to disease progression and hypertension. By studying various forms of CKD in mice, the researchers aim to understand the mechanisms by which renal nerve activity influences kidney function and inflammation. The study will also explore the potential of renal denervation as a treatment option for CKD, particularly in patients who have not responded well to existing therapies. Insights gained from this research could lead to novel therapeutic strategies for managing CKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic kidney disease, particularly those who have not responded adequately to current treatments.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve kidney function and slow the progression of chronic kidney disease.
How similar studies have performed: Previous research has shown promise in using renal denervation for hypertension, but this specific approach in chronic kidney disease is still being explored.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAN, RODERICK JASON — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: TAN, RODERICK JASON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: chronic kidney disease