How REDD1 affects insulin-controlled genes in the heart
The role of REDD1 in insulin-mediated transcription
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11371467
This research looks at how the protein REDD1 changes insulin’s control of genes in heart cells for people with type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11371467 on ClinicalTrials.gov |
What this research studies
If you have type 2 diabetes, this work explores how REDD1 affects insulin signaling in heart muscle and may contribute to diabetic cardiomyopathy. Researchers use genome-wide gene activity tests, mouse heart tissue, and cell models, plus high-fat diet and fatty-acid experiments, to see how insulin and diet change REDD1 levels and location inside cells. They will examine how REDD1 interacts with the mTORC1 pathway and whether those changes make heart cells more or less sensitive to insulin. The project is lab-based and aims to reveal molecular targets that could lead to new treatments to restore heart insulin sensitivity.
Who could benefit from this research
Good fit: Adults with type 2 diabetes, particularly those at risk for or showing signs of diabetic heart disease, are the most relevant population.
Not a fit: People without type 2 diabetes or whose heart disease is caused by non–insulin-resistance mechanisms may not receive direct benefit.
Why it matters
Potential benefit: Could point to new treatments that restore heart insulin sensitivity and help prevent or slow diabetic cardiomyopathy.
How similar studies have performed: Related laboratory studies have linked REDD1 to insulin and mTOR signaling, but its specific role in diabetic hearts remains novel and has not yet led to therapies.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PFLEGER KARCH, JESSICA — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: PFLEGER KARCH, JESSICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Cardiovascular Diseases