How red blood cells contribute to kidney injury after blood flow loss
Official title: Red blood cell trapping mediates toxic kidney injury following ischemia
Funded at Augusta University · NIH-10981042 · Data updated 2026-11-12
This study is looking into how severe blood flow loss can cause kidney damage, especially by understanding how red blood cells get stuck in the kidneys, and it aims to find better ways to help patients recover from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 6, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $581,737 |
| NIH project number | 1R01DK138150-01A1 |
| Project ID | NIH-10981042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe hypotension or shock leading to acute kidney injury.
✕Less likely to help
Patients with chronic kidney disease unrelated to acute ischemic events may not benefit from this research.
What this research studies
This research investigates the mechanisms behind acute kidney injury (AKI) that occurs after severe blood flow loss, such as during shock or ischemia. It focuses on the phenomenon of red blood cell trapping in the kidney, which leads to significant damage and poor recovery outcomes for patients. By studying animal models, the research aims to uncover the processes that cause this trapping and the resulting kidney injury, with the hope of identifying new treatment strategies. The findings could provide insights into why current treatments are ineffective and how to improve patient care.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and outcomes for patients suffering from acute kidney injury.
How similar studies have gone: Previous research has shown that understanding the mechanisms of ischemic injury can lead to breakthroughs in treatment, suggesting that this approach has potential for success.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: O'connor, Paul Michael — Augusta University
- Study coordinator: O'connor, Paul Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.