How red blood cells affect bleeding and oxygen levels in brain hemorrhage patients
Official title: Erythrocyte contribution to coagulopathy and cerebral oxygenation after intracerebral hemorrhage
Funded at Columbia University Health Sciences · NIH-10907522 · Data updated 2026-11-12
This study is looking at how low levels of red blood cells might affect recovery for people who have had a type of stroke called intracerebral hemorrhage, and it aims to find better ways to help these patients heal and avoid complications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $189,433 |
| NIH project number | 5K23HL151901-04 |
| Project ID | NIH-10907522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have recently experienced an intracerebral hemorrhage and may have low red blood cell levels.
✕Less likely to help
Patients who have not experienced an intracerebral hemorrhage or those with stable red blood cell levels may not benefit from this research.
What this research studies
This research investigates the role of red blood cells in patients who have experienced an intracerebral hemorrhage (ICH), a type of stroke that can lead to severe complications. The study aims to understand how low levels of red blood cells may contribute to ongoing bleeding and reduced oxygen delivery to the brain, which can worsen patient outcomes. By examining the relationship between red blood cell levels, coagulation, and cerebral oxygenation, the research seeks to identify better treatment strategies to prevent complications after ICH. The approach includes analyzing patient data and potentially developing targeted transfusion protocols to improve recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that enhance recovery and reduce complications for patients suffering from intracerebral hemorrhage.
How similar studies have gone: While there is evidence linking low red blood cell levels to poor outcomes in other types of brain injuries, this specific approach in intracerebral hemorrhage is novel and has not been extensively tested.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Roh, David — Columbia University Health Sciences
- Study coordinator: Roh, David
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
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-
Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
-
Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
-
Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
-
Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.