How red blood cell transfusions affect brain inflammation and development in anemic newborns
RBC transfusion exacerbates brain inflammation in anemic murine neonates and causes long term neurodevelopment impairment
This study looks at how blood transfusions for anemic newborns might affect their brain health and development, helping us find ways to reduce any negative effects while treating their anemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11029304 on NIH RePORTER |
What this research studies
This research investigates the impact of red blood cell transfusions on brain inflammation and neurodevelopment in anemic newborns. It focuses on understanding how these transfusions, while necessary for treating severe anemia, may inadvertently lead to brain inflammation and long-term cognitive impairments. The study employs a preclinical murine model to explore the mechanisms linking anemia, transfusions, and neurodevelopmental outcomes, aiming to identify potential therapeutic strategies to mitigate these adverse effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants or critically ill newborns who require red blood cell transfusions due to severe anemia.
Not a fit: Patients who are not newborns or do not require red blood cell transfusions for anemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that minimize brain inflammation and enhance neurodevelopment in anemic newborns receiving transfusions.
How similar studies have performed: Previous studies have indicated a connection between red blood cell transfusions and neurodevelopmental impairments, suggesting that this research builds on established findings rather than exploring a completely novel approach.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Krishnan, Mohan Kumar — University of Nebraska Medical Center
- Study coordinator: Krishnan, Mohan Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.