How reactive nitrogen affects bacteria and our health
Elucidating the role of reactive nitrogen species in bacterial interactions
This project explores how certain natural chemicals help good bacteria fight off bad bacteria to keep us healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11113828 on NIH RePORTER |
What this research studies
We are learning how different types of bacteria interact with each other in complex groups, especially how they compete for resources and defend themselves. This project focuses on understanding how natural chemicals called reactive nitrogen species (RNS) influence these bacterial communities. We believe that beneficial bacteria might use RNS to overcome harmful bacteria and maintain a healthy balance within a body. Using advanced laboratory methods and fruit flies, we aim to uncover the exact ways RNS control these interactions between helpful and harmful bacteria.
Who could benefit from this research
Good fit: Patients who experience bacterial imbalances or infections might ultimately benefit from new strategies developed from this fundamental understanding.
Not a fit: Patients whose conditions are not related to bacterial interactions or host immunity would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to support beneficial bacteria in fighting infections and maintaining overall health.
How similar studies have performed: While previous work has looked at RNS with single bacterial species, this project takes a novel approach by focusing on complex communities and their impact on host health.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Scoffield, Jessica a — University of Alabama at Birmingham
- Study coordinator: Scoffield, Jessica a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.