How RANKL signaling affects the immune response to Salmonella infection
Official title: The impact of host RANKL signaling on Salmonella Typhimurium pathogenesis
Funded at Vanderbilt University · NIH-11065834 · Data updated 2026-11-12
This study is looking at how a protein called RANKL affects immune cells called monocytes and their ability to fight off infections like Salmonella, with the goal of finding better ways to help our bodies respond to bacterial infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $34,336 |
| NIH project number | 1F30AI181466-01A1 |
| Project ID | NIH-11065834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by Salmonella or those with compromised immune systems.
✕Less likely to help
Patients with non-bacterial infections or those not affected by immune response issues may not benefit from this research.
What this research studies
This research investigates the role of RANKL signaling in monocytes, a type of immune cell, and how it influences their response to bacterial infections, specifically Salmonella Typhimurium. The study aims to understand how RANKL affects the ability of monocytes to fight off infections by altering their gene expression and inflammatory responses. By examining the interactions between RANKL and monocytes, researchers hope to uncover new insights into the immune system's functioning and its ability to combat bacterial pathogens. This could lead to improved strategies for treating infections and enhancing immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for enhancing immune responses against bacterial infections.
How similar studies have gone: Previous research has shown that understanding immune signaling pathways can lead to significant advancements in treating infections, indicating potential success for this approach.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Si, Clara — Vanderbilt University
- Study coordinator: Si, Clara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.