How random gene expression affects cell fate decisions in the visual system
Official title: Transcription and chromatin dynamics controlling stochastic cell fate specification
Funded at Johns Hopkins University · NIH-11163718 · Data updated 2026-11-12
This study looks at how certain cells in fruit flies decide between two different paths as they develop, which could help us understand similar processes in humans, especially in conditions like autism.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31EY037588-01 |
| Project ID | NIH-11163718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would include individuals diagnosed with autism spectrum disorder or related developmental conditions.
✕Less likely to help
Patients with conditions unrelated to cell fate specification or those over 21 years old may not receive direct benefits from this research.
What this research studies
This research investigates how cells in the developing visual system of fruit flies make random choices between different fates, specifically focusing on the R7 photoreceptor cells. By studying the expression of a transcription factor called Spineless, which influences whether these cells develop into one of two types, the research aims to uncover the underlying mechanisms of stochastic cell fate specification. The project utilizes genetic manipulation and observation of gene expression patterns to understand how variability in these processes can lead to different outcomes in cell development. Insights gained could have implications for understanding similar processes in humans, particularly in conditions like autism spectrum disorder.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of the biological mechanisms behind cell fate decisions, potentially leading to new therapeutic strategies for conditions like autism spectrum disorder.
How similar studies have gone: Other research has shown success in understanding stochastic processes in cell fate decisions, but this specific approach in the context of autism spectrum disorder is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Steinson, Emma — Johns Hopkins University
- Study coordinator: Steinson, Emma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.