How radiation affects thinking and memory in people with glioma
Official title: Mechanisms of Radiation-Induced Neurocognitive Decline (MIND): Longitudinal Study of Imaging Biomarkers and Risk and Resilience Factors Underlying Cognitive Phenotypes in Patients with Glioma
Funded at University of California, San Diego · NIH-11241113 · Data updated 2026-11-12
This project will track brain scans and thinking skills over time to find patterns and risks for memory and thinking problems after radiation in adults with glioma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 5, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $654,111 |
| NIH project number | 5R01CA289833-02 |
| Project ID | NIH-11241113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (age 21 and older) with a diagnosis of glioma who are scheduled to receive or have recently received brain radiotherapy are the ideal candidates.
✕Less likely to help
People without glioma, those under 21, or those not receiving brain radiotherapy are unlikely to be eligible or directly benefit from this project.
What this research studies
You would be followed before and after brain radiation with repeated thinking and memory tests and advanced brain scans. Researchers will use detailed cognitive profiles ('phenotypes') rather than a single test score to describe how thinking changes for different people. They will combine structural, microstructural, and blood-vessel imaging to look for brain changes that link radiation to cognitive problems. The team will also study tumor features, treatment details, and personal factors to find who is more likely to be harmed or resilient.
Why it matters
Potential benefit: If successful, this work could help doctors tailor radiotherapy to protect thinking and memory and guide interventions to preserve cognitive function.
How similar studies have gone: Prior studies have linked radiotherapy to cognitive decline and shown imaging changes, but this comprehensive, longitudinal combination of cognitive phenotyping and multimodal imaging is relatively novel.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hattangadi-Gluth, Jona a — University of California, San Diego
- Study coordinator: Hattangadi-Gluth, Jona a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.