How radiation affects blood vessel cells in brain tumors
Radiation-induced vascular reprogramming in glioblastoma
This study is looking at how radiation therapy affects the blood vessels in glioblastoma, a tough type of brain tumor, to see if it makes tumor cells act like blood vessel cells, which could help the tumor grow back after treatment, with the hope of finding better ways to help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10989964 on NIH RePORTER |
What this research studies
This research investigates how radiation therapy influences the blood vessels in glioblastoma, a highly aggressive brain tumor. It focuses on understanding how radiation can cause tumor cells to transform into blood vessel-like cells, which may support tumor growth after treatment. By studying these changes in both laboratory settings and animal models, the research aims to uncover the mechanisms behind this process and identify potential targets for new therapies. The ultimate goal is to improve treatment outcomes for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing radiation therapy.
Not a fit: Patients with glioblastoma who are not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the effectiveness of existing glioblastoma treatments.
How similar studies have performed: Other research has shown that targeting the vascular changes in tumors can lead to improved treatment outcomes, suggesting that this approach may hold promise.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kornblum, Harley Ian — University of California Los Angeles
- Study coordinator: Kornblum, Harley Ian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.