How pyruvate affects the development of myofibroblasts in myelofibrosis.
Official title: The impact of pyruvate metabolic fate in myofibroblast differentiation in myelofibrosis.
Funded at University of Utah · NIH-11065017 · Data updated 2026-11-12
This study is looking at how changing the way certain cells in your bone marrow use energy might help stop the scarring that happens in myelofibrosis, with the hope of finding new treatments that could improve your blood cell production and ease your symptoms.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $78,892 |
| NIH project number | 1F32HL177926-01 |
| Project ID | NIH-11065017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myelofibrosis who are experiencing symptoms related to bone marrow scarring.
✕Less likely to help
Patients with other types of blood disorders or those not diagnosed with myelofibrosis may not benefit from this research.
What this research studies
This research investigates the role of pyruvate metabolism in the differentiation of myofibroblasts, which are cells that contribute to the scarring of bone marrow in myelofibrosis. The study aims to understand how inhibiting lactate export from fibroblasts can prevent the transformation into myofibroblasts, potentially reversing fibrosis and improving blood cell production. By analyzing gene expression and signaling pathways, the research seeks to identify new treatment strategies that could alter the disease's progression and alleviate symptoms for patients. The approach involves pharmacological interventions targeting specific transporters involved in lactate metabolism.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reverse fibrosis and improve blood cell production in patients with myelofibrosis.
How similar studies have gone: While there has been some exploration of metabolic interventions in fibrosis, this specific approach targeting lactate export in myelofibrosis is relatively novel and untested.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Krah, Nathan Michael — University of Utah
- Study coordinator: Krah, Nathan Michael
Related research
Other NIH-funded projects on the same topics.
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Strategies to deplete myelofibrosis stem cells using HDM2/p53 pathway
A patient-focused program tests a therapy that may selectively reduce disease-causing blood stem cells in people with myelofibrosis.
-
Megakaryocyte changes in myelofibrosis and its progression to leukemia
A scientist-guided project will study how abnormal megakaryocytes and signals like TGF-β and IL-13 may drive progression from myelofibrosis toward acute leukemia, with potential implications for future treatments.
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Molecular clues and new therapies for myelofibrosis and related blood cancers
This grant supports research to understand what drives myelofibrosis and related disorders and to develop new treatment ideas for patients.
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Myelofibrosis and the bone marrow environment: how inflammation changes blood production
A doctor-researcher is studying how inflammation in the bone marrow affects the blood-forming system in people with myeloproliferative neoplasms (MPNs) to find ways to prevent scarring and leukemia.
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Early detection of treatment response in myelofibrosis using a new imaging technology
A new, quick imaging method could tell patients with myelofibrosis early whether a treatment is working.
-
MYC-driven vulnerability in myelofibrosis could guide new therapies
A new project is exploring how the MYC protein contributes to myelofibrosis and whether it can be targeted to help people with this blood cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.