How pyrazinamide affects tuberculosis bacteria metabolism
The impact of pyrazinamide on metabolism in Mycobacterium tuberculosis
This study is looking at how the tuberculosis drug pyrazinamide works against tough bacteria and how our genes and immune system might affect its success, using animal models to help understand these factors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11041135 on NIH RePORTER |
What this research studies
This research investigates the effects of pyrazinamide (PZA), a key drug in tuberculosis treatment, on the metabolism of Mycobacterium tuberculosis. It aims to understand how PZA works effectively against slow-growing bacteria that are resistant to other treatments. The study will explore genetic factors that contribute to resistance and the role of the immune system in the drug's effectiveness. By using animal models, researchers will assess how these factors influence treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those who may have drug-resistant strains.
Not a fit: Patients with non-tuberculosis infections or those who do not have active tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tuberculosis treatments and reduced relapse rates for patients.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of tuberculosis treatment, making this approach both relevant and potentially impactful.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Baughn, Anthony D — University of Minnesota
- Study coordinator: Baughn, Anthony D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.