How puberty affects kidney health in youth with diabetes
Puberty, diabetes, and the kidneys, when eustress becomes distress
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11141485
This study is looking at how puberty affects kidney health in kids aged 8-14 who have type 2 diabetes and obesity, to see if the changes during this time can harm their kidneys, and it hopes to find ways to keep their kidneys healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11141485 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of puberty on kidney health in adolescents with type 2 diabetes and obesity. It aims to understand how the changes during puberty may lead to kidney injury by examining factors like kidney oxygen levels and energy use. The study will enroll adolescents aged 8-14, comparing those with obesity and elevated blood sugar levels to healthy peers, using advanced imaging techniques and kidney function tests over a two-year period. By identifying the mechanisms behind kidney damage, the research seeks to find ways to protect kidney function in at-risk youth.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 8-14 with obesity and elevated hemoglobin A1c levels.
Not a fit: Patients who are not adolescents or do not have diabetes or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preserving kidney function in adolescents with diabetes.
How similar studies have performed: Previous research has shown that understanding metabolic changes during puberty can provide insights into complications like kidney disease, suggesting this approach has potential for success.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BJORNSTAD, PETTER — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: BJORNSTAD, PETTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Brittle Diabetes Mellitus