How puberty affects kidney health in youth with diabetes
Official title: Puberty, diabetes, and the kidneys, when eustress becomes distress
Funded at Seattle Children's Hospital · NIH-11141485 · Data updated 2026-11-12
This study is looking at how puberty affects kidney health in kids aged 8-14 who have type 2 diabetes and obesity, to see if the changes during this time can harm their kidneys, and it hopes to find ways to keep their kidneys healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 19, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $515,650 |
| NIH project number | 7R01DK129211-04 |
| Project ID | NIH-11141485 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents aged 8-14 with obesity and elevated hemoglobin A1c levels.
✕Less likely to help
Patients who are not adolescents or do not have diabetes or obesity may not benefit from this research.
What this research studies
This research investigates the impact of puberty on kidney health in adolescents with type 2 diabetes and obesity. It aims to understand how the changes during puberty may lead to kidney injury by examining factors like kidney oxygen levels and energy use. The study will enroll adolescents aged 8-14, comparing those with obesity and elevated blood sugar levels to healthy peers, using advanced imaging techniques and kidney function tests over a two-year period. By identifying the mechanisms behind kidney damage, the research seeks to find ways to protect kidney function in at-risk youth.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preserving kidney function in adolescents with diabetes.
How similar studies have gone: Previous research has shown that understanding metabolic changes during puberty can provide insights into complications like kidney disease, suggesting this approach has potential for success.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Bjornstad, Petter — Seattle Children's Hospital
- Study coordinator: Bjornstad, Petter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.