How psychiatric medicines can interact with other drugs
Drug interactions involving psychoactive drugs
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11249147
This project looks at whether commonly prescribed psychiatric medicines can cause harmful interactions with other drugs, especially in older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11249147 on ClinicalTrials.gov |
What this research studies
As a patient, you can expect the team to analyze large collections of medical records and prescription data to find real-world cases where psychiatric drugs were combined with other medicines. They will look at clinical outcomes like hospital stays, injurious falls, venous thromboembolism (VTE), and serious bleeding to see if those events are linked to drug combinations. The focus is on older adults who commonly take multiple drugs and are at higher risk. Results aim to improve drug-interaction warnings and the alerts doctors get when prescribing.
Who could benefit from this research
Good fit: Ideal candidates are older adults who take one or more prescription psychiatric drugs along with other medications, especially those with multiple chronic conditions or recent hospitalizations.
Not a fit: People not taking prescription psychiatric drugs or those whose care involves only non-drug treatments are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could reduce harmful drug interactions and prevent hospitalizations, serious bleeding, VTE, and injuries among people taking psychiatric medications.
How similar studies have performed: Previous work has mostly been case reports or drug-concentration studies and has linked some psychiatric drug combinations to more falls, while systematic study of VTE and serious bleeding is largely new.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEONARD, CHARLES EDWARD — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LEONARD, CHARLES EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.