How psilocybin affects brain circuits after chronic stress
Circuit Mechanisms of Psilocybin Following Chronic Stress
This study is looking at how a single dose of psilocybin, a natural compound found in certain mushrooms, can help people with chronic stress by changing the way their brains work, especially in areas that are often affected by stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11101140 on NIH RePORTER |
What this research studies
This research investigates the effects of psilocybin, a psychedelic compound, on brain circuits in individuals experiencing chronic stress. It aims to understand how a single dose of psilocybin can lead to long-lasting therapeutic changes in the brain, particularly focusing on the prefrontal cortex, which is often impaired in stress-related disorders. By examining the neural mechanisms involved, the study hopes to uncover how psilocybin promotes neuroplasticity and improves mental health outcomes. The research involves both human participants and animal models to explore these effects comprehensively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic stress or related neuropsychiatric conditions.
Not a fit: Patients who do not experience chronic stress or have contraindications for psilocybin use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a rapid and effective treatment option for individuals suffering from stress-related neuropsychiatric disorders.
How similar studies have performed: Previous research has shown promising results with psilocybin in promoting therapeutic effects, indicating potential success for this approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Ahmed, Omar Jamil — University of Michigan at Ann Arbor
- Study coordinator: Ahmed, Omar Jamil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.