How Pseudomonas aeruginosa evolves in plumbing and affects cystic fibrosis
Evolution of Pseudomonas aeruginosa in premise plumbing and impact on cystic fibrosis respiratory disease pathogenesis
['FUNDING_OTHER'] · CARNEGIE-MELLON UNIVERSITY · NIH-11082322
This study looks at how a germ called Pseudomonas aeruginosa, which can cause serious lung infections, changes and grows in building plumbing, especially to help protect people with cystic fibrosis from getting sick.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CARNEGIE-MELLON UNIVERSITY (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11082322 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacteria Pseudomonas aeruginosa, which can cause severe respiratory infections, evolves in the plumbing systems of buildings. It focuses on understanding the conditions in plumbing that allow this bacteria to thrive and potentially lead to infections in individuals with cystic fibrosis. By studying the biofilms that form in water pipes and faucets, the research aims to uncover how these bacteria adapt to their environment and how this adaptation may influence their ability to cause disease. The findings could help in developing strategies to prevent infections in vulnerable patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cystic fibrosis who are at risk of respiratory infections.
Not a fit: Patients without cystic fibrosis or those not exposed to Pseudomonas aeruginosa may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for respiratory infections in cystic fibrosis patients.
How similar studies have performed: Other research has shown that understanding bacterial evolution in specific environments can lead to significant advancements in infection control, suggesting this approach has potential for success.
Where this research is happening
PITTSBURGH, UNITED STATES
- CARNEGIE-MELLON UNIVERSITY — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARMBRUSTER, CATHERINE REBECCA — CARNEGIE-MELLON UNIVERSITY
- Study coordinator: ARMBRUSTER, CATHERINE REBECCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections