How Pseudomonas aeruginosa affects drug metabolism in cystic fibrosis patients
Official title: Impact of Pseudomonas aeruginosa cytochrome P450 enzymes and secondary metabolites on drug metabolism and disposition in the cystic fibrosis patient
Funded at University of Colorado Denver · NIH-10999438 · Data updated 2026-11-12
This study looks at how a common bacteria in cystic fibrosis patients affects the way antibiotics work, with the goal of finding better treatments to help you feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 11, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $678,232 |
| NIH project number | 5R01AI176245-02 |
| Project ID | NIH-10999438 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cystic fibrosis patients who are experiencing infections caused by Pseudomonas aeruginosa.
✕Less likely to help
Patients without cystic fibrosis or those not infected with Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates how the bacteria Pseudomonas aeruginosa influences the metabolism of drugs, particularly antibiotics, in patients with cystic fibrosis. It focuses on the role of specific enzymes and metabolites produced by the bacteria that may alter the effectiveness of treatments like ciprofloxacin. By understanding these interactions, the research aims to identify new targets for antimicrobial therapies and improve treatment outcomes for patients. The study employs a combination of biochemical analysis and patient samples to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved antibiotic treatments for cystic fibrosis patients, enhancing their health outcomes.
How similar studies have gone: Other research has shown promising results in understanding the impact of pathogens on drug metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Lampe, Jed Noah — University of Colorado Denver
- Study coordinator: Lampe, Jed Noah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.