How proteins that transport vesicles affect centrosomes
Official title: Role of Vesicular Trafficking Proteins in Regulating Centrosomes
Funded at University of Tulsa · NIH-10974077 · Data updated 2026-11-12
This study is looking at how certain proteins help with cell division by affecting tiny structures called centrosomes, using a small worm as a model, to better understand diseases like cancer and microcephaly that can happen when these structures don’t work properly.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tulsa NIH-funded |
| Lab location | 1 site (Tulsa, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $426,000 |
| NIH project number | 1R15GM152965-01A1 |
| Project ID | NIH-10974077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by conditions related to centrosome dysfunction, such as certain cancers or developmental disorders.
✕Less likely to help
Patients with conditions unrelated to centrosome function or those not exhibiting any cellular abnormalities may not benefit from this research.
What this research studies
This research investigates the role of specific proteins involved in vesicular trafficking and their impact on centrosomes, which are crucial for cell division. Using the model organism C. elegans, the study aims to uncover how proteins like clathrin and dynamin influence centrosome function and organization. By understanding these cellular mechanisms, the research seeks to shed light on the underlying causes of diseases associated with centrosome dysfunction, such as cancer and primary microcephaly.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases linked to centrosome abnormalities.
How similar studies have gone: While the specific approach using C. elegans is novel, previous studies have shown success in understanding cellular mechanisms related to centrosome function.
Where this research is happening
-
University of Tulsa
Tulsa, United States Active
Researchers
- Principal investigator: Iyer, Jyoti — University of Tulsa
- Study coordinator: Iyer, Jyoti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.