How proteins that bind RNA affect gene expression and splicing
Mechanisms of Post-transcriptional Gene Regulation by RNA Binding Proteins
This study is looking at how certain proteins help control gene activity and the way genes are put together in mammals, which could give us important clues about diseases like ALS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11087835 on NIH RePORTER |
What this research studies
This research investigates the role of RNA binding proteins in regulating gene expression and alternative splicing in mammals. By isolating and characterizing splicing regulatory complexes, the study aims to uncover new interactions and functions of these proteins and their associated RNAs. Advanced techniques such as cryo-electron microscopy will be employed to visualize the structures of these complexes, providing insights into their mechanisms of action. The findings could enhance our understanding of gene regulation and its implications for diseases like ALS.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals diagnosed with amyotrophic lateral sclerosis (ALS) or related disorders.
Not a fit: Patients with conditions unrelated to RNA binding or gene regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to gene regulation, including ALS.
How similar studies have performed: Previous research has shown promising results in understanding RNA binding proteins and their roles in gene regulation, indicating that this approach has potential for significant discoveries.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Black, Douglas L — University of California Los Angeles
- Study coordinator: Black, Douglas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.