How proteins regulate gene expression in response to stimuli
Temporal coordination of stimulus-induced gene expression by RNA-binding proteins
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10887551
This study is looking at how certain proteins in our bodies help control gene activity when we face different challenges, especially in the adrenal glands, to better understand how hormones like aldosterone, which helps manage blood pressure, are produced when our immune system is activated.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10887551 on ClinicalTrials.gov |
What this research studies
This research investigates how RNA-binding proteins (RBPs) control gene expression in response to external stimuli, focusing on the adrenal glands. It aims to understand the mechanisms by which these proteins influence the processing, decay, and translation of RNA, particularly in the context of immune activation and hormone production. By studying human adrenal steroidogenesis, the research will explore how the binding of Angiotensin II to its receptor affects the production of aldosterone, a key hormone in regulating blood pressure. The findings could provide insights into the timing and regulation of gene expression during cellular responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with disorders related to adrenal gland function or blood pressure regulation.
Not a fit: Patients with unrelated endocrine disorders or those not experiencing issues with adrenal function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to adrenal function and blood pressure regulation.
How similar studies have performed: Previous research has shown that understanding RNA-binding proteins can significantly impact our knowledge of gene regulation, suggesting potential for success in this area.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUKHERJEE, NEELANJAN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: MUKHERJEE, NEELANJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.