How proteins in our cell membranes work and contribute to diseases like cancer
Molecular mechanism of regulation and activation of membrane proteins in native membrane milieu
This project aims to understand how important proteins in our cell membranes are organized and activated, which could help us learn more about diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11117162 on NIH RePORTER |
What this research studies
Our cells are surrounded by membranes that contain many important proteins, which are organized into tiny areas called nanodomains. These nanodomains help control how cells communicate and function, and when they don't work correctly, it can lead to diseases like cancer, nerve disorders, and immune problems. This research is developing new ways to look closely at these membrane proteins in their natural environment. By using a special technique to create 'native nanodiscs,' we can better understand how these proteins are organized and how they become active.
Who could benefit from this research
Good fit: Patients with conditions like cancer, neurodegenerative diseases, or immune disorders could eventually benefit from the knowledge gained from this fundamental research.
Not a fit: Patients without conditions related to membrane protein dysfunction would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into how diseases like cancer develop, potentially leading to new strategies for diagnosis and treatment.
How similar studies have performed: This project aims to develop novel experimental approaches for studying membrane proteins in their native environment, addressing a current scarcity of such methods.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Bhattacharyya, Moitrayee — Yale University
- Study coordinator: Bhattacharyya, Moitrayee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.