How proteins control the movement of membranes in brain cells
Spatial control of membrane traffic by septin GTPases
This study is looking at how certain proteins help control the movement of important structures in brain cells, which could help us understand and find new treatments for diseases like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11089870 on NIH RePORTER |
What this research studies
This research investigates how specific proteins, known as septins, regulate the movement of membrane-bound structures within brain cells and other polarized cell types. By understanding the mechanisms behind this spatial control, the research aims to uncover new insights into how disruptions in membrane traffic can lead to diseases like Alzheimer's and other neurodegenerative conditions. The approach involves studying the interactions between septins and other cellular components, focusing on their role in maintaining cell polarity and function. Patients may benefit from the findings as they could lead to innovative treatments for conditions associated with impaired membrane traffic.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those diagnosed with Alzheimer's or related conditions.
Not a fit: Patients with non-neurological conditions or those without any form of neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases such as Alzheimer's.
How similar studies have performed: Other research has shown promising results in understanding membrane traffic in cells, suggesting that this approach could yield significant insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Spiliotis, Elias T — University of Virginia
- Study coordinator: Spiliotis, Elias T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.