How proteins change in specific brain cells in Alzheimer's
Cell Specific Perturbations of the Proteome in Alzheimer's Disease
Researchers are mapping protein changes in different brain cell types in people with Alzheimer's to help explain memory loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11134640 on NIH RePORTER |
What this research studies
This project looks at how proteins change in specific brain cell types from people with Alzheimer’s and older adults without dementia. Scientists use advanced proteomics tools to measure proteins from isolated cell types and synapses, often using donated brain tissue or patient-derived samples. By comparing cell-specific protein patterns, the team aims to find early molecular changes that relate to memory and thinking problems.
Who could benefit from this research
Good fit: Ideal participants are people aged 65 or older with Alzheimer’s disease, or family members willing to provide consent for donation of biological samples or post-mortem brain tissue.
Not a fit: People without Alzheimer's, younger adults, or those unable or unwilling to provide biological samples or tissue donations are unlikely to directly benefit from participating.
Why it matters
Potential benefit: If successful, this work could reveal new biological targets and markers that help detect or treat early Alzheimer's-related synaptic loss.
How similar studies have performed: Broad proteomics work has found Alzheimer's-linked protein changes, but detailed mapping of proteins by specific human brain cell type is a newer approach with limited prior human data.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Yates Iii, John R — Scripps Research Institute, the
- Study coordinator: Yates Iii, John R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.