How proteins are made in cells and their role in cancer
Molecular mechanisms of eukaryotic translational control
This study is looking at how certain proteins help control the process of making other proteins in our cells, especially in cancer, to find new ways to improve treatment and survival for patients with aggressive cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11034057 on NIH RePORTER |
What this research studies
This research investigates how the synthesis of proteins in cells is controlled, particularly focusing on the role of eukaryotic translation initiation factors (eIFs). It aims to understand how these factors can influence which mRNAs are translated into proteins, especially in the context of cancer progression and metastasis. By studying specific factors like eIF4B, which has shown potential in improving survival rates in aggressive cancers, the research seeks to uncover mechanisms that could lead to new therapeutic strategies. Patients may benefit from insights into how these processes can be targeted in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with aggressive forms of cancer, particularly breast cancer.
Not a fit: Patients with non-cancerous conditions or those with early-stage cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival rates for patients with aggressive cancers.
How similar studies have performed: Previous research has shown promising results in targeting translation mechanisms in cancer therapy, suggesting that this approach could be effective.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Walker, Sarah Elizabeth — State University of New York at Buffalo
- Study coordinator: Walker, Sarah Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.