How proteins and DNA work together in our cells
Activities of nucleoprotein complexes visualized in single-molecule experiments
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-10993684
This project helps us understand how proteins and DNA interact to build our chromosomes, which is vital for our health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10993684 on ClinicalTrials.gov |
What this research studies
Our bodies rely on DNA and proteins working together perfectly to form chromosomes. This project uses special tools to look closely at these interactions, one molecule at a time. We want to learn how proteins attach to and detach from DNA, and how large protein complexes help fold chromosomes inside our cells. This detailed view helps us uncover the basic rules that govern our genetic material, which is key to understanding genetic disorders and fighting diseases.
Who could benefit from this research
Good fit: While this is foundational science, future treatments stemming from this work could help patients with genetic disorders or conditions related to cell division.
Not a fit: Patients whose conditions are unrelated to fundamental genetic or chromosomal processes may not directly benefit from this specific basic science work.
Why it matters
Potential benefit: A deeper understanding of how our chromosomes are built and maintained could lead to new ways to address genetic disorders and fight various diseases.
How similar studies have performed: This project aims to revise current understandings of protein-DNA interactions and chromosome folding, suggesting a novel approach to fundamental biological questions.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARKO, JOHN F — NORTHWESTERN UNIVERSITY
- Study coordinator: MARKO, JOHN F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.