How protein sequences affect the movement of molecules across cell membranes
Official title: Protein sequence influence on single-molecule transport dynamics
Funded at Columbia Univ New York Morningside · NIH-10946299 · Data updated 2026-11-12
This study is looking at how special proteins help move vitamin B12 in and out of cells, using a cool new technique that lets scientists see this process in real-time, which could help us understand how these proteins work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $323,941 |
| NIH project number | 1R01GM155677-01 |
| Project ID | NIH-10946299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to ABC transporter deficiencies or related metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to ABC transporters or those not affected by molecular transport issues may not benefit from this research.
What this research studies
This research investigates the role of ATP-Binding Cassette (ABC) Transporters, which are essential for transporting various substances across cell membranes using energy from ATP. By employing a cutting-edge single-molecule fluorescence resonance energy transfer (smFRET) technique, the study aims to observe the real-time movement of vitamin B12 during its transport process. This approach allows researchers to uncover the dynamic mechanisms of transport that are not visible through traditional methods, potentially leading to new insights into how these transporters function at a molecular level.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of molecular transport processes, potentially leading to improved treatments for diseases related to transporter dysfunction.
How similar studies have gone: Previous research has shown promising results using similar techniques to study molecular transport, indicating that this approach could yield valuable insights.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Hunt, John Francis — Columbia Univ New York Morningside
- Study coordinator: Hunt, John Francis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.