How protein phosphorylation affects cell organization and function
Official title: The role of phosphorylation in the cellular organization of the proteome
Funded at University of Washington · NIH-10764019 · Data updated 2026-11-12
This study is looking at how tiny changes in proteins, called phosphorylation, help organize proteins in our cells and how this affects how different types of cells respond to the same signals, which could be important for understanding various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $419,850 |
| NIH project number | 1R35GM152061-01 |
| Project ID | NIH-10764019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diseases or conditions linked to cellular signaling and protein function, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or protein phosphorylation may not benefit from this research.
What this research studies
This research investigates the role of protein phosphorylation in regulating how proteins are organized within cells. By using advanced experimental and computational techniques, the team aims to understand how phosphorylation influences cellular responses to various signals. The study will identify specific phosphorylation sites that are crucial for protein functions and explore how these modifications affect the overall organization of the cellular proteome. This work is essential for understanding the differences in how various cell types respond to the same stimuli.
Why it matters
Potential benefit: If successful, this research could lead to new insights into disease mechanisms and potential therapeutic targets for conditions related to abnormal protein phosphorylation.
How similar studies have gone: Previous research has shown promising results in understanding cellular signaling through similar approaches, indicating a strong potential for success in this area.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Villen, Judit — University of Washington
- Study coordinator: Villen, Judit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.