How protein modifications in the heart affect health and disease
Official title: Protein S-Palmitoylation in the Heart: Function and Regulation in Health and Disease
Funded at Virginia Commonwealth University · NIH-10986988 · Data updated 2026-11-12
This study is looking at how a special change to proteins in heart cells might affect heart health, and it's for anyone interested in understanding more about heart conditions and potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $373,062 |
| NIH project number | 5R01HL163101-03 |
| Project ID | NIH-10986988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with or at risk for heart diseases, particularly those with conditions related to protein modifications.
✕Less likely to help
Patients with non-cardiac conditions or those without any heart disease risk factors may not benefit from this research.
What this research studies
This research investigates the role of a specific protein modification called palmitoylation in heart cells, focusing on how it influences heart health and disease. By studying the palmitoylome, which is the collection of proteins that can undergo palmitoylation, the researchers aim to understand how changes in this process can lead to heart conditions. The study involves advanced techniques to analyze proteins in human, dog, and rat hearts, identifying key proteins and enzymes involved in this modification. The goal is to uncover mechanisms that could lead to new treatments for heart diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart diseases by targeting the palmitoylation process.
How similar studies have gone: Previous research has shown promising results in understanding protein modifications in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Tseng, Gea-Ny — Virginia Commonwealth University
- Study coordinator: Tseng, Gea-Ny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.