How protein degradation affects daily and seasonal biological timing
Protein degradation mechanisms that regulate daily and seasonal timing
This study looks at how certain proteins in plants help them keep track of time and adapt to changes in day length throughout the seasons, using the plant Arabidopsis as a model to understand these processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10907438 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which protein degradation influences the circadian clock and seasonal timing in organisms, particularly using the plant model Arabidopsis. It focuses on understanding how these processes synchronize biological functions with environmental changes, such as day length. The research employs advanced techniques to explore the role of E3 ubiquitin ligases in regulating these timing mechanisms. By uncovering these interactions, the study aims to provide insights into how organisms adapt their physiology to daily and seasonal variations.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing circadian rhythm disorders or related affective disorders.
Not a fit: Patients with conditions unrelated to circadian rhythms or seasonal timing may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of biological timing, which may have implications for treating disorders related to circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms and their regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Gendron, Joshua Martin — Yale University
- Study coordinator: Gendron, Joshua Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.