How protein damage contributes to esophageal cancer development
Official title: Regulation of esophageal tumorigenesis by protein adduction
Funded at University of Miami School of Medicine · NIH-11005308 · Data updated 2026-11-12
This study is looking at how certain changes in proteins might lead to esophageal cancer in people with GERD, helping us understand more about what causes this type of cancer and how it develops.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $76,750 |
| NIH project number | 5R03CA286671-02 |
| Project ID | NIH-11005308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with gastroesophageal reflux disease.
✕Less likely to help
Patients without a history of gastroesophageal reflux disease or those with other unrelated esophageal conditions may not benefit from this research.
What this research studies
This research investigates the role of protein adduction in the development of esophageal adenocarcinoma, particularly in patients with gastroesophageal reflux disease (GERD). It focuses on how certain lipid derivatives, formed from oxidative stress, can bind to proteins in the esophagus and potentially lead to cancerous changes. By understanding these molecular mechanisms, the research aims to uncover new insights into how esophageal tumors develop and progress. Patients with GERD may find this research relevant as it seeks to identify the underlying causes of their condition and its link to cancer.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies or treatments for esophageal cancer in patients with GERD.
How similar studies have gone: While the specific approach of investigating protein adduction in esophageal cancer is novel, similar studies have shown success in understanding cancer mechanisms related to other types of malignancies.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Caspa Gokulan, Ravindran — University of Miami School of Medicine
- Study coordinator: Caspa Gokulan, Ravindran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.