How proteases affect the spread of prostate cancer.
Official title: Regulation of extracellular proteases in prostate cancer progression to a metastatic phenotype
Funded at University of Nebraska Medical Center · NIH-11061676 · Data updated 2026-11-12
This study is looking at how certain enzymes in the body might help prostate cancer become more aggressive, with the hope of finding new ways to treat or prevent advanced prostate cancer that could benefit patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $138,214 |
| NIH project number | 3R01CA276846-02S1 |
| Project ID | NIH-11061676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with prostate cancer, particularly those at risk of developing metastatic disease.
✕Less likely to help
Patients with non-cancerous conditions or those with advanced metastatic prostate cancer may not benefit from this research.
What this research studies
This research investigates the role of extracellular proteases in the progression of prostate cancer to a more aggressive metastatic form. By examining how these enzymes regulate cancer cell behavior, the study aims to uncover potential targets for new therapies. Patients may benefit from insights that could lead to improved treatment strategies or preventive measures against advanced prostate cancer. The research employs laboratory techniques to analyze protease activity and its impact on cancer cell dynamics.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent the spread of prostate cancer.
How similar studies have gone: Previous research has shown that targeting proteases can be effective in managing cancer progression, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Bergan, Raymond C. — University of Nebraska Medical Center
- Study coordinator: Bergan, Raymond C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.