How prostaglandins affect cell movement and tissue repair
Prostaglandins and actin remodeling
['FUNDING_OTHER'] · UNIVERSITY OF IOWA · NIH-11030821
This study is looking at how certain natural substances in the body, called prostaglandins, help cells move and repair tissues, which could lead to better treatments for diseases like cancer and heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11030821 on ClinicalTrials.gov |
What this research studies
This research investigates the role of prostaglandins, which are lipid signaling molecules, in regulating cell movement and tissue repair. By understanding how these molecules influence actin remodeling, the study aims to uncover new insights into their functions in various diseases, including cancer and cardiovascular conditions. The approach involves examining the specific pathways and cellular mechanisms that prostaglandins activate to promote collective cell migration. This could lead to the development of more targeted therapies that improve healing and reduce disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to abnormal tissue repair, such as cancer patients or those with cardiovascular diseases.
Not a fit: Patients with stable conditions that do not involve tissue repair or cell migration issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for conditions related to abnormal tissue repair and cancer metastasis.
How similar studies have performed: While many studies have explored cell migration, this specific focus on prostaglandins and actin remodeling is relatively novel and has not been extensively tested.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOOTLE, TINA L — UNIVERSITY OF IOWA
- Study coordinator: TOOTLE, TINA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.