How proline hydroxylation activates protein kinases involved in brain tumors
Official title: Activation of protein kinases by proline hydroxylation
Funded at University of Miami School of Medicine · NIH-11007279 · Data updated 2026-11-12
This study is looking at how a specific change in proteins might help activate important enzymes that could affect brain tumor growth and behavior, with the hope that this knowledge could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | January 5, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $446,036 |
| NIH project number | 5R01CA280560-02 |
| Project ID | NIH-11007279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with brain tumors or those with cancer stem cell characteristics.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by brain tumors are unlikely to benefit from this research.
What this research studies
This research investigates the role of proline hydroxylation in activating protein kinases that are crucial for regulating cellular processes in brain tumors. The study focuses on understanding how specific kinases, particularly DYRK1A and DYRK1B, are activated through a process that involves the modification of proteins by prolyl-hydroxylation. By exploring these molecular pathways, the research aims to uncover mechanisms that could influence the behavior of cancer stem cells and tumor growth in the brain. Patients may benefit from insights gained into how these processes can be targeted for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for brain tumors by targeting the activation mechanisms of key protein kinases.
How similar studies have gone: Previous research has shown promising results in targeting protein kinases for cancer treatment, indicating that this approach may yield significant insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Lasorella, Anna — University of Miami School of Medicine
- Study coordinator: Lasorella, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.