How prolactin receptors affect muscle pain sensitivity differently in males and females after injury
Official title: Sex dependent effects of prolactin receptor on muscle hypersensitivity following ischemic insult
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10995749 · Data updated 2026-11-12
This study is looking at how a certain receptor in the body affects muscle pain after an injury, especially to see why women might feel more pain than men, with the goal of finding new ways to help manage that pain.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 12, 2024 |
| Project end | July 11, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,574 |
| NIH project number | 1F31NS135995-01A1 |
| Project ID | NIH-10995749 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic musculoskeletal pain, particularly females who may have heightened sensitivity to pain.
✕Less likely to help
Patients who do not experience chronic musculoskeletal pain or those with conditions unrelated to ischemic injury may not benefit from this research.
What this research studies
This research investigates how the prolactin receptor influences muscle pain sensitivity following ischemic injury, particularly focusing on differences between males and females. It aims to understand the biological mechanisms behind heightened pain sensitivity in females, which may lead to chronic musculoskeletal pain. The study will analyze the role of specific genes and proteins involved in pain signaling in the dorsal root ganglia of both sexes. By examining these differences, the research seeks to identify potential therapeutic targets for pain management.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies tailored to gender-specific responses in patients suffering from chronic musculoskeletal pain.
How similar studies have gone: Previous research has shown success in understanding sex differences in pain mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Quijas, Meranda — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Quijas, Meranda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.