How prolactin affects heart adaptation during and after pregnancy
Prolactin receptor signaling regulates adaptation of the heart during pregnancy and postpartum
This study is looking at how a specific hormone receptor in the heart helps it cope with the changes that happen during and after pregnancy, aiming to find ways to improve heart health for new moms.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10802415 on NIH RePORTER |
What this research studies
This research investigates how the prolactin receptor (PRLR) signaling in the heart helps it adapt to the physiological changes that occur during pregnancy and the postpartum period. The study aims to understand the role of lactogenic hormones in regulating heart function during these critical times. By examining the signaling pathways activated by PRLR in heart cells, researchers hope to uncover new insights into how the heart adjusts to the demands of pregnancy and recovers afterward. This could lead to better understanding and management of heart health in new mothers.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are pregnant or have recently given birth.
Not a fit: Patients who are not pregnant or have not recently given birth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart health strategies for women during and after pregnancy.
How similar studies have performed: While the specific role of PRLR signaling in the heart during pregnancy is novel, related research has shown success in understanding hormonal impacts on other maternal tissues.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Young, Martin E — University of Alabama at Birmingham
- Study coordinator: Young, Martin E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.