How progranulin insufficiency affects TDP-43 in dementia
Interactions between progranulin insufficiency and TDP-43
This study is looking at how low levels of a protein called progranulin might affect another protein linked to Frontotemporal Dementia (FTD) and how these changes could impact behavior, especially in social situations, to help find new ways to treat FTD.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11188947 on NIH RePORTER |
What this research studies
This research investigates the relationship between progranulin insufficiency and TDP-43 pathology in patients with Frontotemporal Dementia (FTD). Using a genetic mouse model, the study examines how a lack of progranulin protein influences the mislocalization and aggregation of TDP-43, a protein associated with FTD. The research focuses on behavioral changes and neurological impacts, particularly in social dominance behaviors, to understand the underlying mechanisms of this condition. By exploring these interactions, the study aims to shed light on potential therapeutic targets for FTD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Frontotemporal Dementia or those diagnosed with FTD linked to progranulin mutations.
Not a fit: Patients with other forms of dementia unrelated to progranulin insufficiency or TDP-43 pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from Frontotemporal Dementia.
How similar studies have performed: Previous research has shown promising results in understanding TDP-43 pathology in other neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Cook, Anna K — University of Alabama at Birmingham
- Study coordinator: Cook, Anna K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.