How progranulin insufficiency affects TDP-43 in dementia
Official title: Interactions between progranulin insufficiency and TDP-43
Funded at University of Alabama at Birmingham · NIH-11188947 · Data updated 2026-11-12
This study is looking at how low levels of a protein called progranulin might affect another protein linked to Frontotemporal Dementia (FTD) and how these changes could impact behavior, especially in social situations, to help find new ways to treat FTD.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | June 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,629 |
| NIH project number | 5F30AG085889-02 |
| Project ID | NIH-11188947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of Frontotemporal Dementia or those diagnosed with FTD linked to progranulin mutations.
✕Less likely to help
Patients with other forms of dementia unrelated to progranulin insufficiency or TDP-43 pathology may not benefit from this research.
What this research studies
This research investigates the relationship between progranulin insufficiency and TDP-43 pathology in patients with Frontotemporal Dementia (FTD). Using a genetic mouse model, the study examines how a lack of progranulin protein influences the mislocalization and aggregation of TDP-43, a protein associated with FTD. The research focuses on behavioral changes and neurological impacts, particularly in social dominance behaviors, to understand the underlying mechanisms of this condition. By exploring these interactions, the study aims to shed light on potential therapeutic targets for FTD.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from Frontotemporal Dementia.
How similar studies have gone: Previous research has shown promising results in understanding TDP-43 pathology in other neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Cook, Anna K — University of Alabama at Birmingham
- Study coordinator: Cook, Anna K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.