How prenatal opioid exposure affects brain development and behavior in offspring
Mechanisms of prenatal opioid exposure on brain and behavior
This study looks at how being exposed to opioids during pregnancy affects newborns' brains and behaviors, especially focusing on how medications like buprenorphine might lead to developmental challenges, like ADHD, in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11082413 on NIH RePORTER |
What this research studies
This research investigates the effects of maternal opioid exposure during pregnancy on the brain and behavior of newborns. It focuses on understanding how medications used to treat opioid use disorder, like buprenorphine, may lead to developmental issues in children. The study employs a novel mouse model to explore the cellular mechanisms involved in brain development and how these changes may contribute to behavioral problems such as ADHD. By examining these relationships, the research aims to uncover critical insights into the impact of prenatal opioid exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women undergoing treatment for opioid use disorder and their newborns.
Not a fit: Patients who are not pregnant or those who have not been exposed to opioids during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for children affected by prenatal opioid exposure.
How similar studies have performed: Previous research has indicated that maternal substance exposure can lead to developmental issues, suggesting that this study's approach is both relevant and necessary.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Wu, Ping — University of Texas Med Br Galveston
- Study coordinator: Wu, Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.