How prenatal exposure to PFAS affects adolescent heart and metabolic health
Official title: Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
Funded at Brown University · NIH-11146028 · Data updated 2026-11-12
This study is looking at how being exposed to certain chemicals during pregnancy might affect the heart and metabolism of kids as they grow up, especially in terms of weight and insulin levels, by checking blood samples from moms and their children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $67,416 |
| NIH project number | 3R01ES032836-04S1 |
| Project ID | NIH-11146028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women and their children, particularly those living in areas with known PFAS contamination.
✕Less likely to help
Patients who are not pregnant or who do not have a history of PFAS exposure may not benefit from this research.
What this research studies
This research investigates the impact of prenatal exposure to perfluoroalkyl substances (PFAS) on the cardiometabolic health of adolescents. It focuses on understanding how these chemical mixtures, commonly found in food packaging and cleaning products, may influence health outcomes like obesity and insulin resistance. By analyzing blood samples from mothers and their children, the study aims to identify biological markers that link PFAS exposure to long-term health effects. The research utilizes advanced metabolomics techniques to explore these associations over time.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for cardiometabolic diseases in adolescents exposed to harmful chemicals during pregnancy.
How similar studies have gone: Previous studies have shown concerning links between PFAS exposure and health outcomes, but this specific approach to studying PFAS mixtures and their long-term effects is relatively novel.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Braun, Joseph M — Brown University
- Study coordinator: Braun, Joseph M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.